SHARE INDIA , MediCiti Institute of Medical Sciences.
Kalpana Betha, MD, Professor and Head of Department, OBY, MIMS
K. Govind Narsingrao MD, Professor and Head of Department, Community Health, MIMS
PS Reddy, MD, Chairman of SHARE INDIA
University of Pittsburgh Consultant:
Catherine L. Haggerty, PhD, MPH, Associate Professor and Director of the Reproductive, Perinatal and Pediatric Epidemiology Area of Emphasis University of Pittsburgh Graduate School of Public Health, Department of Epidemiology, Pittsburgh, PA, USA http://www.publichealth.pitt.edu/home/directory/catherine-l-haggerty
Kusneniwar GN, Whelan RM, Betha K, Robertson JM, Ramidi PR, Balasubramanian K, Kamasamudram V, Haggerty CL, Bunker CH, Reddy PS. Cohort Profile: The Longitudinal Indian Family hEalth (LIFE) Pilot Study, Telangana State, India. International Journal of Epidemiology. 2017 Jun 1; 46(3):788-789j. PMID: 27649805. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837391/
Funding source: GATI Limited.
Amount: Rs. 33 Lakhs (201 8-19).
Status of Field work from 1 st April, 2018 to 31 st March, 2019
|Deliveries at MediCiti Hospital (MIMS)||8|
|Deliveries at Outside Hospitals||2|
|PNC -1 month follow up||12|
|Child Follow -up visits (No. of questionnaires completed by age of the child)|
|No of Children screened for mental health problems in the age group of 3-4 years||89|
|6-7years children follow up||396|
|No. of under five children deaths||0|
|8-16 years children follow up|
|96-98montfis follow up visit||99|
|WISC-IV scale (8 -11 years)||116|
Funding source: Fogarty International Center - NIH.
Amount: US $46,318 (2016-19).
Aims: To reduce the burden of poor pregnancy outcomes due to reproductive tract infections in India.
Determine the role of pre-pregnancy and prenatal vaginal infections with mollicutes including fastidious Mycoplasma genitalium and the newly differentiated Ureaplasma spp. termed U. urealyticum (UU) and U. parvum (UP) in Pre-Term Birth (PTB) and Spontaneous abortion (SAB). The study also aims to determine the relationships between vaginal infection with Mycoplasma genitalium, Ureaplasma urealyticum, Ureaplasma parvum, and adverse pregnancy outcomes, including spontaneous abortion and preterm birth. It also examines chorioamnionitis as a mediating factor between Mycoplasma genitalium or Ureaplasma infection and spontaneous preterm birth.
Status of the project
The project is studying 1 88 women who delivered preterm, 21 8 women who experienced spontaneous abortion and 436 control women who delivered at term in the LIFE study. RT PCR isolation of DNA was completed from 2000 samples. Seven probes were standardized. Completed PCR testing for 100 samples for Trichomonas and Mycoplasma genitalium.
To characterize and compare the pre-pregnancy vaginal microbiota of:
a) pregnant women who subsequently experience a spontaneous abortion
b) women who subsequently deliver preterm, to a control group of women who deliver at term To characterize and compare the vaginal microbiota at labor and delivery among women who deliver preterm and a control group of women who deliver at term
Status of the project:
The project is studying 20 cases of women with spontaneous abortion, 20 cases of women who delivered preterm and 20 control women who delivered at term. Archived preconception vaginal samples were analyzed using broad range 16S rRNA gene PCR with sequencing. The interim report showed more sequence reads from Sneathia species, Megasphaera species and Atopobium vaginae than controls. Women who delivered at term had vaginal microbiota dominated by lactobacillus sp.
Partial support from Texas A&M University.
Amount: US $ 24,000 (2017-19).
a) Determine if circulating pre-pregnancy and first trimester biomarkers of placental dysfunction (EGFL7, PIGF,sFLT-l, PP-13) are associated with SAB
b) Determine if circulating pre-pregnancy and early pregnancy DAMPs (HGBM-1, HSP70) and innate immune signaling biomarkers (Pentraxin-3) are associated with SAB
c) Determine if pre-pregnancy and early pregnancy circulating markers of oxidative stress (MDA,GDH) are associated with SAB
Examine the relationship between early pregnancy serum markers of cellular damage, innate immune signaling, angiogenesis and preeclampsia subtypes.
Status of the project
The project is studying 50 cases of women who had spontaneous abortion and 100 control women who delivered at term. First pregnancies with
Funding source :NIH through University of Pittsburgh.
Amount: US $ 936,756.
To examine a broad range of preconception and prenatal serum biomarkers in the above Cardiovascular Disease (CVD) pathways in relation to the risk of Pre-Term Birth (PTB).
Determine if preconception biomarkers: lipid, inflammatory/immune, glucose, blood pressure and vitamin D predict PTB. Examine longitudinal changes in the above biomarkers across pregnancy (preconception, first and third trimester and delivery) in relation to PTB. Examine shared pathways leading to pregnancy loss and PTB. Status of the project: Grant applied, approval is awaited.